Heterogeneity of neuroblastoma

Heterogeneity of neuroblastoma.

Commentary on: Prokineticin signaling is required for the maintenance of a de novo population of c-KIT+ cells to sustain neuro-blastoma progression. Neuroblastoma (NB) is the most common pediatric solid tumor and represents 15% of all childhood cancer deaths. High cellular heterogeneity is a hallmark of NB, which may account for the wide range of clinical presentations and non-uniform response ...

Heterogeneity of the MYCN oncogene in neuroblastoma.

PURPOSE MYCN amplification is an important therapy-stratifying marker in neuroblastoma. Fluorescence in situ hybridization with signal detection on the single-cell level allows a critical judgement of MYCN intratumoral heterogeneity. EXPERIMENTAL DESIGN The MYCN status was investigated by fluorescence in situ hybridization at diagnosis and relapse. Heterogeneity was defined as the simultaneou...

HETEROGENEITY OF MACROPHAGE POPULATIONS: ANTIBODIES DETECTING VARIOUS POPULATIONS OF MACROPHAGES

Two groups of antibodies against mouse resident alveolar and peritoneal macrophages have been raised individually in rabbits by immunization with whole cell suspensions of lavaged alveolar and peritoneal macrophages. The whole antisera reacted positively with neutrophils and lymphocytes. However, upon extensive absorptions with these cells the activity became restricted to macrophages. The...

Bone Involvement in Neuroblastoma

REGRESSION OF METASTATIC NEUROBLASTOMA TO GANGLIONEUROMA

The spontaneous regression of neuroblastoma to ganlioneuroma is a rare occurrence. Reviewing the literature, we found no more than 12casesreported.'•2.9.,o.'4.1s We report a case of metastatic neuroblastoma of multifocal skeletal and soft tissue areas with gross deformities which regressed to ganglioneuroma, with good prognosis.